Dexrazoxane Treatment for Intrathoracic Anthracycline Extravasation
نویسندگان
چکیده
منابع مشابه
Dexrazoxane treatment for intrathoracic anthracycline extravasation.
treatment of an intrathoracic epirubicin extravasation [3]. Approximately 140 mg of epirubicin extravasated into the pleural space when the tip of an implanted port catheter became misplaced. A pleural drain was inserted and the pleural cavity was immediately flushed with 1000 ml normal saline on 2 consecutive days. Dexrazoxane was also infused intravenously for the first three consecutive days...
متن کاملTreatment of anthracycline extravasation with dexrazoxane.
Accidental extravasation of anthracyclines is a feared complication. Present treatment consists of local cooling and extensive surgical debridement, which often results in severe morbidity. All clinically important anthracyclines are topoisomerase II poisons that are antagonized by topoisomerase II catalytic inhibitors such as dexrazoxane. Therefore, we investigated whether dexrazoxane protects...
متن کاملAnthracycline extravasation injuries: management with dexrazoxane
The application of anthracyclines in anticancer therapy may result in accidental extravasation injury and can be a serious complication of their use. Tissue necrosis with skin ulceration is a possible outcome in the inadvertent extravasation of anthracyclines during intravenous administration. Until recently, there has been no effective treatment against the devastating effect of extravasated a...
متن کاملDexrazoxane (Totect): FDA review and approval for the treatment of accidental extravasation following intravenous anthracycline chemotherapy.
Management of anthracycline extravasation is problematic and most reports are anecdotal. On September 6, 2007, the U.S. Food and Drug Administration approved Totect 500 mg (dexrazoxane hydrochloride for injection) for the treatment of extravasation resulting from i.v. anthracycline chemotherapy. In two studies, a total of 57 evaluable patients experienced extravasation from peripheral vein or c...
متن کاملTreatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies.
BACKGROUND The purpose of this study was to assess the efficacy and tolerability of i.v. dexrazoxane [Savene (EU), Totect (US)] as acute antidote in biopsy-verified anthracycline extravasation. PATIENTS AND METHODS Two prospective, open-label, single-arm, multicentre studies in patients with anthracycline extravasation were carried out. Patients with fluorescence-positive tissue biopsies were...
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ژورنال
عنوان ژورنال: Oncology Research and Treatment
سال: 2008
ISSN: 2296-5270,2296-5262
DOI: 10.1159/000160618